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Organic compounds with acidic properties, organic acids are generally weak acids incapable of complete dissociation in water. Available in a range of chemical compositions and acid strengths, they can be used for various industrial and everyday applications.
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MRTX-EX185 formic is a potent KRAS (G12D) inhibitor with an IC50 of 90 nM. It binds to both GDP-loaded and active GNP states of KRAS and KRAS (G12D). This compound exhibits broad-spectrum binding properties and can be utilized for studying various RAS-driven tumors, such as pancreatic cancer.
Suppresses cell proliferation in KRAS (G12D)-driven SW-1990 pancreatic cancer cells with an IC50 of 70 nM.
Non-toxic to non-KRAS-dependent cell lines (HEK293 cells).
Significantly inhibits ERK phosphorylation (p-ERK) in KRAS(G12C)-driven cell lineages.
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Succinic acid-d6 is the deuterium-labeled version of Succinic acid, an intermediate product of the tricarboxylic acid cycle and a fermentation product of anaerobic metabolism. It is intended for research use only and is not sold to patients.
Used as a tracer.
Serves as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
High purity of 99.0%.
Appears as a solid.
Color is white to off-white.
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